Seth Doege passed for six touchdowns and a season-high 499 yards as Texas Tech shocked No. 5 West Virginia 49-14, ending the Mountaineers' hopes for an unbeaten season.
The Red Raiders fans stormed the field after the win, the most lopsided Texas Tech victory ever against a team ranked in the top five.
Texas Tech's defense consistently stymied West Virginia's offense. Heisman Trophy hopeful Geno Smith completed 29 of 55 passes for 275 yards.
The Red Raiders offense had no trouble moving the ball as Doege threw TD passes of 39, 19, 16, 2, 29 and 7 yards. He completed 32 of 42 passes and the six touchdowns matched his career-high. Darrin Moore caught three touchdown passes.
Texas Tech (5-1, 2-1 Big 12) had 18 plays of 15 yards or more, including a 61-yard pass to Jace Amaro and a 53-yard touchdown run by SaDale Foster.
Amaro finished with five receptions for 156 yards.
West Virginia fell to 5-1, 2-1.
NO. 6 KANSAS STATE 27,
IOWA STATE 21
Quarterback Collin Klein ran for 105 yards and three touchdowns as Kansas State held off Iowa State for its fifth straight win against the Cyclones.
Klein also threw for 187 yards for the Wildcats (6-0, 3-0 Big 12), who remain unbeaten heading into next week's showdown with West Virginia.
Kansas State held the Cyclones (4-2, 1-2) to just 231 yards of offense. Iowa State still had a chance for the game-winning drive from its own 3-yard line with 2:17 left, but the Wildcats stopped the Cyclones on downs.
NO. 10 OREGON STATE 42, BYU 24
Cody Vaz passed for 332 yards and three touchdowns in his first start since high school and Oregon State used a strong start and bigger finish to beat Brigham Young (4-3).
Markus Wheaton caught two first-quarter TD passes, and scored on a 12-yard reverse in the fourth, while cornerback Jordan Poyer returned an interception 49 yards to seal the win.
Oregon State is 5-0 for the first time since 1939.
NO. 11 USC 24, WASHINGTON 14
Anthony Brown blocked a punt and returned it 21 yards for a touchdown in the first half, Jawanza Starling forced and recovered Keith Price's fumble inside the USC 5-yard line in the fourth quarter, and the Trojans (5-1, 3-1 Pac-12) overcame offensive inconsistency to defeat Washington (3-3, 1-2).
Silas Redd rushed for 108 yards and a touchdown in the first half and Matt Barkley added an 18-yard TD pass to Xavier Grimble for the Trojans.
NO. 13 OKLAHOMA 63,
NO. 15 TEXAS 21
Damien Williams broke off a 95-yard touchdown run for the longest rush in Red River Rivalry history, Blake Bell powered his way in for four TDs and Oklahoma (4-1, 2-1 Big Ten) beat Texas (3-2, 1-2) for its second straight blowout in the series.
Landry Jones threw for 321 yards and two touchdowns, and fullback Trey Millard had a career-best 119 yards for the Sooners.
Stoops is now 9-5 against Mack Brown and responsible for three of Oklahoma's five most lopsided wins over Texas — and that doesn't include last year's 55-17 clobbering.
NO. 24 BOISE STATE 20,
FRESNO STATE 10
D.J. Harper rushed for 117 yards and a touchdown and Joe Southwick threw for another score to lead Boise State (5-1, 2-0 Mountain West) past Fresno State (4-3, 2-1).
Harper was the leader of a Boise State rushing attack that chewed up 215 yards on the ground and propelled the Broncos to their seventh straight victory over the Bulldogs.
Southwick put the Broncos up in the first quarter when he fired a 10-yard touchdown to Geraldo Boldewijn in the left corner of the end zone. Southwick was 11 of 22 for 113 yards passing and one interception.