CHICAGO - Carlos Quentin hit a tiebreaking homer leading off the bottom of the seventh, closer Bobby Jenks escaped a ninth-inning jam and the White Sox made it two straight against the Cubs with a 6-5 victory Saturday.
Quentin drove an 0-2 pitch from Carlos Marmol for an opposite-field home run into the Cubs' bullpen in right field - his 18th of the season - to snap the 5-5 tie.
Derrek Lee was 5-for-5 with three RBIs for the Cubs, who've lost seven of 11. He led off the top of the ninth with a double and moved to third on an infield out. But Lee was stranded when Jenks got Aramis Ramirez to ground out to short with the infield in and retired Jim Edmonds on a grounder to second.
Jermaine Dye and Alexei Ramirez also homered for the White Sox, who were swept last weekend by the Cubs but have rebounded and won four of five.
Matt Thornton, the third of five White Sox relievers, pitched 12/3 perfect innings, striking out four of the five batters he faced to get the win. Jenks' save was his 18th in 21 chances.
Cubs starter Sean Gallagher worked six innings, giving up eight hits and five runs, including a two-run homer to Dye in the first and a tying solo shot to Ramirez in the fourth.
White Sox starter Javier Vazquez labored through 41/3 innings, allowing nine hits and five runs with three walks.
The Cubs scored two in the top of the first when the first four batters reached. Kosuke Fukudome walked and Mark DeRosa, Lee and Daryle Ward singled to give Gallagher an early two-run cushion he couldn't maintain.
Dye hit a two-out, two-run homer to tie it - his eighth homer in the last 12 games and 18th of the season. After Jim Thome walked, Joe Crede doubled off the left-field fence and as the ball bounded past DeRosa, Thome scored for a 3-2 lead. Orlando Cabrera's RBI double made it 4-2 in the second.
The Cubs loaded the bases in the third on two singles and a walk, but Sox third baseman Crede made a fully extended catch of Geovany Soto's liner in the hole to end the inning.