Quinn Cook scored a career-high 27 points and No. 1 Duke held Clemson to its lowest-scoring half in 12 years in a 68-40 victory against the Tigers on Tuesday night.
Ryan Kelly added 12 points in the first half but sat out the second with what team officials said was a right leg injury.
The Blue Devils (15-0, 2-0 Atlantic Coast Conference) shot 48 percent, built a 42-31 rebounding advantage and pulled away down the stretch to improve to 58-4 at home against the Tigers.
Devin Booker had 12 points and 15 rebounds for Clemson (8-6, 0-2), which had season lows for points and shooting percentage (28) and shot 12 percent in its brutal first half.
The Tigers had just 10 points at halftime, their fewest since scoring nine against Wake Forest in 2001.
Still, Clemson made things interesting briefly in the second half, closing to 34-22 with 151/2 minutes left.
NO. 10 MISSOURI 84,
Jabari Brown hit a career-high five straight 3-pointers after an early miss and Phil Pressey responded from a shaky first half with 11 points and 13 assists, leading Missouri past Alabama in its SEC debut.
Trevor Releford had a career-best 26 points with three 3-pointers and topped 1,000 points for Alabama (8-6, 0-1), which has lost six of eight. Coach Anthony Grant lost for the first time in seven conference openers, three at VCU and four at Alabama.
Earnest Ross added 19 points for Missouri (12-2, 1-0).
NO. 13 CREIGHTON 91,
Ethan Wragge matched career highs with 22 points and six 3-pointers and Creighton (15-1, 4-0 Missouri Valley Conference) got off to a blistering start on its way to a victory against Drake (6-9, 0-4).
Doug McDermott added 16 points, Jahenns Manigat had 13 and Grant Gibbs 10 for the Bluejays, who've won nine in a row.
Creighton has won 71 straight games against opponents .500 or worse.
NO. 15 OHIO STATE 74,
Deshaun Thomas scored 22 points to lead Ohio State past Purdue.
The angry Buckeyes (12-3, 2-1) rebounded from their first Big Ten loss by shooting 56.4 percent from the field. They took a 10-point halftime lead despite losing point guard Aaron Craft for all but 4:19 of the first half because of early foul trouble, and Buckeyes coach Thad Matta got his 100th Big Ten victory.
Purdue (7-8, 1-2) has lost two straight to Top 20 teams since upsetting No. 11 Illinois last week.
NO. 19 GEORGETOWN 45
Talib Zanna scored 15 points, and Pittsburgh (13-3, 1-2 Big East) rediscovered its shooting touch, hitting 55 percent in its victory against Georgetown (10-3, 0-2).
Zanna went 7-for-9 from the field, and Tray Woodall added 11 points and seven assists for the Panthers, who dominated the Hoyas from the opening tip to bounce back from two Big East losses that knocked them out of the Top 25.
No player scored in double figures for the punchless Hoyas, who shot 35 percent to lose by more than 20 points at home for the first time in 13 years.