Zach Collaros threw for 214 yards and ran for two touchdowns as No. 23 Cincinnati took firm control of the Big East race with a 26-23 win over Pittsburgh on Saturday night.
Isaiah Pead rushed for 118 yards and Tony Miliano kicked four field goals for the Bearcats (7-1, 3-0), who won their sixth straight and took a significant step toward winning the program's third conference title in four years.
Pitt (4-5, 2-2) led by 10 early in the third quarter but a pair of turnovers deep in its territory allowed Cincinnati to get back in the game.
Tino Sunseri ran for a touchdown and passed for another but Kevin Harper's 50-yard field goal attempt with 14 seconds left was wide right.
The Bearcats appeared to be in serious trouble after the Panthers took a 23-13 lead early in the third quarter on Sunseri's 4-yard toss to tight end Hubie Graham.
Yet Cincinnati rallied by doing what it has done all season: Forcing opponents into careless turnovers and turning them into points.
NO. 24 W. VIRGINIA 35
Teddy Bridgestone threw for one touchdown, Andrew Johnson returned a blocked field goal for another score and Louisville beat No. 24 West Virginia.
Not expected to be a factor in the Big East this season, the Cardinals (5-4, 3-1) won their third straight in a tight race and dealt a big blow to West Virginia's title chances.
Louisville also got a payback of sorts after being overlooked in the recent Big 12 expansion sweepstakes, a bid that went to the Mountaineers.
Three different backs scored rushing touchdowns for Louisville, which broke a four-game losing streak in the series.
Geno Smith threw for 410 yards and three scores but couldn't bring the Mountaineers (6-3, 2-2) back from 10 points down in the fourth quarter.
Quarterback Scott McCummings ran for two touchdowns and Lyle McCombs ran for 152 yards and a score to lead Connecticut past Syracuse, keeping alive the Huskies' hopes for a winning season.
After being used as a change-of-pace option for much of the game, McCummings took over the offense for UConn (4-5, 2-2) in the fourth quarter, and led them on an eight-play, 62-yard drive, running the ball in from 7 yards for the winning score with just under 5 minutes to play.
Ryan Nassib threw for 275 yards and two touchdowns for Syracuse (5-4, 1-3), which failed for the second straight week to become bowl eligible.
It was the fifth straight win for UConn against Syracuse.