Matt Scott had 469 total yards and accounted for four touchdowns, helping Arizona overcome a huge day by Southern California's Marqise Lee to beat the 10th-ranked Trojans 39-36 on Saturday.
Lee caught 16 passes for a Pac-12-record 345 yards and two touchdowns to help USC (6-2, 4-2 Pac-12) build a 15-point lead midway through the third quarter.
But Scott led Arizona (5-3, 2-1) back, throwing for 369 yards and three touchdowns, including a 7-yarder to David Richards that put the Wildcats up 39-28 with just over 5 minutes left.
The Trojans answered quickly with Silas Redd's second rushing touchdown, from 10 yards, but remain stuck on 799 wins as a program after Matt Barkley's last-ditch pass into the end zone was swatted down.
Scott finished 27-for-50 passing and ran for 100 yards before missing Arizona's final possession with an undisclosed injury.
Austin Hill had 10 catches for 259 yards to help the Wildcats hold on for the upset win after coming up short against the Trojans a year ago.
Barkley threw for 493 yards and three touchdowns, but threw two interceptions.
NO. 2 OREGON 70, COLORADO 14
Kenjon Barner rushed for 104 yards and two touchdowns, as Oregon (8-0, 5-0 Pac-12) easily took care of Colorado (1-7, 1-4).
De'Anthony Thomas rushed for another score and added a 73-yard punt return for a touchdown before most of the Ducks' offensive starters were pulled midway through the second quarter. Redshirt freshman quarterback Marcus Mariota passed for 136 yards and two TDs.
The Ducks built a 56-0 lead by halftime and their 70 points were the most they'd ever scored against a conference opponent. It was Oregon's 11th straight overall victory.
Christian Powell rushed for 127 yards and two touchdowns for the Buffaloes, who lost their fourth straight.
NO. 19 STANFORD 24,
WASHINGTON ST. 17
Ed Reynolds returned an interception for a touchdown and Stanford (6-2, 4-1 Pac-12) sacked Jeff Tuel 10 times to overcome a sloppy offensive effort in a victory against Washington State (2-6, 0-5).
Reynolds stepped in front of Tuel's pass for the safety's fourth interception — and second returned for a score — this season early in the fourth quarter. He ran 25 yards to give the Cardinal a two-touchdown lead.
NO. 21 BOISE STATE 45,
D.J. Harper rushed for 105 yards and two touchdowns to lead Boise State (7-1, 4-0 Mountain West) past Wyoming (1-7, 0-4) for its seventh straight win.
Harper scored on runs of 12 and 3 yards, and Joe Southwick completed 20 of 28 passes for 198 yards and one interception for the Broncos. The Boise State offense was an efficient 12 of 14 on third down conversions and scored on all five of its red zone opportunities.
MIAMI (OHIO) 23,
NO. 24 OHIO 20
Ohio gambled by going for one more play instead of a tying field goal, and Tyler Tettleton was sacked as time ran out, preserving Miami of Ohio's upset over the Bobcats.
The Bobcats (7-1, 3-1 Mid-American Conference) played as a ranked team for the first time since 1968, when they finished the season at No. 20. They'd won the last six games in one of the MAC's edgiest rivalries, which added another notable ending.
Kaleb Patterson kicked a 31-yard field goal with 1:24 left, giving Miami (4-4, 3-1) its lead.